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Promethazine hydrochloride for sleeping disorders (Sleeplessness & Sleep Disturbances [5] ). A randomized, double-blind, 6 weeks pilot, clinical trial has shown a statistically significant reduction in sleep disturbances patients with SDE. Sleep disorders are a significant cause of morbidity/mortality and are associated with impaired physical and mental health, reduced quality of life, poor workplace performance and health effects on children [1]. SDEs occur when a patient has insufficient sleep for a prolonged duration and are significant contributor to the morbidity and mortality rate associated with SDEs [2]. The most common causes of SDEs are insufficient sleep and/or excessive sleepiness [3]. apnea is one of the most commonly studied SDEs, with significant prevalence rates of up to 5% and prevalence peaks among those aged 15–24 years [4]. Sleep apnea is defined as a continuous or recurrent lack of breathing during sleep (apnea) or partial complete cessation of breathing during sleep (hypopnea). According to the American Heart Association, approximately 1 in 10 healthy individuals suffer from sleep apnea at any given time and the prevalence of sleep apnea is significantly higher in women than men [5]. Statistical analyses were performed using the SPSS version 19.0 software (SPSS Inc., Chicago, IL, USA) and SAS 9.1 software (SAS Institute Inc., Cary, NC, USA). A two-tailed P value of <.05 was considered statistically significant. Pearson's correlation coefficient was used to determine the relationship between sleep apnea and insomnia. Pearson's correlation coefficient (r) was calculated for each of the six sleep disorders and relationship between apnea insomnia was determined by summing the Pearson's correlation coefficients. coefficient was plotted against the logarithm of sleep apnea prevalence and was used as a measure of the correlation relationship. Patients were excluded from the analysis if they had any history of cardiovascular, respiratory, pulmonary, genitourinary, skin, gastrointestinal, genito-urinary or endocrine diseases and if they were unable to sleep through the night, were unable to perform the study activity, were receiving pharmacological medications or taking known to have an adverse effect on sleep [18]. was assessed as an actigraphy study using the Yale Bedtime Record [18]. Participants were instructed that the study was to be voluntary and non-commissioned, so a signed consent form was not obtained from patients or their parents. All participants were screened out of the study if they failed to meet the following criteria after sleep evaluation: (i) a minimum of one night-shift (≥6 hours in duration) without a minimum of two or more consecutive nights of uninterrupted sleep; (ii) a minimum score of 4.0 (score range 0–5.0) or more on the Yale Bedtime Test [18]; (iii) a minimum of two consecutive night-shift-free nights with a minimum score of 4.0 (score range 0–5.0) promethazine with codeine canada pharmacy or more on the Yale Bedtime Test; (iv) a minimum of three consecutive nights uninterrupted sleep without a minimum score of 4.0 (score range 0–5.0) or more on the Yale Bedtime Test; or (v) a minimum score of 4.0 (score range 0–5.0) on the Mini Sleep Questionnaire (MSQ; [19] ). The study protocol was approved by the Institutional Review Board at University of Michigan. Exclusion criteria included use of sleeping medication or drug products in the previous 6 months, drugstore canada magazine online history of heart disease or stroke, use of non-prescription sleep aids such as benzodiazapines or antipsychotic medications, history of uncontrolled diabetes mellitus (with or without insulin infusion hypoglycemic episodes), heart disease or stroke any condition requiring hospitalization. The study used a population-based sample of healthy subjects and with insomnia or SDE. The participants had a minimum of six sleep nights per week and were recruited through public advertisement, the websites of local health departments and via advertisements in print on the radio network, with an additional 30% of the volunteers referred by health department. The sample was chosen by using a stratified random sample through multiple-pass procedure for selecting subjects from both the community (n = 8,534) and university 5,828) populations. The Pearson's correlation coefficient was calculated between sleep apnea severity and the SDS of insomnia symptom score (SDSI; [19] ). Sleep apnea severity increased from zero, indicating no insomnia, to three, severe insomnia. Pearson's correlation coefficient was 0.5, indicating an increase of 0.5 points in sleep apnea severity for every point in the SDSI. r of Pearson's correlation coefficient ranged from.05 to.
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Persévérer avec Christ/ Persevering with Christ
Par Charles Tchapdeu /By Charles Tchapdeu
Interpreté en Anglais par Tristan Kabongo
Interpreted in English by Tristan Kabongo